Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIGURE 4.
FIGURE 4.

Specific interactions of E site binding. (A) The E site ligands interact with both rRNA (gray) and L44e (green). (B) A76 stacks in between 23S rRNA nucleotides G2459 (2421) and A2460 (2422), and hydrogen bonds with universally conserved C2431 (2394). (C) C75 interacts with L44e through hydrogen bonding to Gly 57 and Arg 40, and hydrophobic packing with Lys 54, Lys 51, and Phe 52.

This Article

  1. RNA 9: 1345-1352

Current Issue

  1. August 2026, 32 (8)
  1. Current Issue
  1. Alert me to new issues of RNA