FIGURE 6.
Model for Py-tract recognition—multiple modes of binding. Both RRM1 and RRM2 contact adjacent uridine stretches (A). In comparison to complex A, only RRM2 binds in a different register in complex B, and both RRMs bind in different registers in complex C. Triangles represent nucleotides or uridines. Double arrows indicate that these complexes are in equilibrium. For simplicity, only three binding sites are shown for each RRM. The actual number of complexes will depend on the length of the Py tract and the number of nucleotides that interact with each RRM.
