Alignment of hSmg5/7b and hSmg5/7c to CeSMG5 and CeSMG7 and DmCG8954, and DmCG6369. (A, B) hSmg5/7b or hSmg5/7c, CeSMG5, CeSMG7, DmCG8954, and DmCG6369 are diagrammed as horizontal bars. The number of constituent amino acids (aa) is provided to the right of each bar. Conserved regions 3 (C3), 4 (C4), and 5 (C5) are boxed and aligned with dashes. Amino acids 173–257 of hSmg5/7b, 130–208 of CeSMG7, 286–370 of DmCG6369, and 211–298 of DmCG8954 can also be aligned at C3. Amino acids 853–924 of hSmg5/7b, 1009–1081 of DmCG8954, and 425–480 of CeSMG5 can be aligned at C4. Amino acids 186–257 of hSmg5/7c can be aligned with amino acids 133–208 of CeSMG7, 288–361 of DmCG6369, and 213–299 of DmCG8954 at C5. White letters in black boxes, white letters in gray boxes, and black letters in gray boxes are as in Figure 1B. (C) Percent (%) identity/similarity between proteins within C3, C4, and C5.
