A 100-kD complex of two RNA-binding proteins from mitochondria of Leishmania tarentolae catalyzes RNA annealing and interacts with several RNA editing components

TABLE 1.

RNA binding and RNA annealing properties of the Ltp26/Ltp28 100 kDa complex and individual recombinant proteins

Single-stranded RNA Double-stranded RNA
Protein Kd (nM) Kd (nM) Fold annealing stimulation
Native complex 9.6 ± 2 2.6 ± 0.3 38
Ltp28 128 ± 21 96 ± 6 67
Lpt26 225 ± 52 259 ± 65 21
Reconstituted complex 24 ± 2 4.5 ± 1.2 N/D

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  1. RNA 9: 62-76

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