miRNA regulation in brain tissue space: the 3′UTR perspective

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FIGURE 1.
FIGURE 1.

Overview of miRNA and 3′UTR biogenesis and their interaction during neurodevelopment and neuronal function. (A) Biogenesis of miRNAs mediated by DROSHA, DGCR8 and DICER until the final mature miRNA is loaded via AGO2 for targeting of mRNA isoforms influencing stability, translation or protein localization of the target mRNA. (B) Examples of miRNAs and their role in neural development. miRNAs can be very specific for certain subcellular compartments.

This Article

  1. Published in Advance February 11, 2026, doi: 10.1261/rna.080850.125 RNA 32: 472-488

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