High-stoichiometry m6A sites are evolutionarily conserved

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FIGURE 2.
FIGURE 2.

Highly methylated m6A sites are the most evolutionarily conserved. (A) Comparison of evolutionary conservation between methylated (m6A+) and unmethylated (m6A−) DRACH sites to matched control (GDBYC) sites using consensus frequency score (CFS) and (B) separated by RNA region. (C) Comparison of CFS of DRACH and control motifs grouped by methylation frequency and (D) separated by RNA region.

This Article

  1. Published in Advance December 18, 2025, doi: 10.1261/rna.080858.125 RNA 32: 328-340

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