Novel trinucleotide mRNA capping reagents: improved synthetic route and efficient cotranscriptional incorporation in mRNA

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIGURE 1.
FIGURE 1.

Natural cap structures on 5′-end of mRNA. Cap 0: R1 and R2 = H; Cap 1: R1 = methyl; R2 = H; Cap 2: R1 = methyl; R2 = methyl; B1, B2, and B3—nucleoside bases.

This Article

  1. Published in Advance November 19, 2025, doi: 10.1261/rna.080634.125 RNA 32: 195-214

Current Issue

  1. August 2026, 32 (8)
  1. Current Issue
  1. Alert me to new issues of RNA