MUTACLASH: identifying functional small RNA target sites using crosslinking-induced mutations

TABLE 1.

Frequency of reads with mRNA deletion or substitution in RNA sequencing data or CLASH data

Library Read type # Reads with deletion # Reads with substitution # Total reads % Reads with mutation
mRNA Non-hybrid (mRNA only) 5166.5 281,215 20,038,571 Deletion: 0.026%
Substitution: 1.40%
PRG-1 CLASH Non-hybrid (mRNA only) 265,382 270,426.5 4,053,251 Deletion: 6.65%
Substitution: 6.76%
ALG-1
iCLIP
Non-hybrid (mRNA only) 875,559.5 1,120,123 15,107,177 Deletion: 5.8%
Substitution: 7.41%
PRG-1 CLASH Hybrid 108,970 129,279 4,017,410 Deletion: 2.8%
Substitution: 3.27%
ALG-1 iCLIP Hybrid 4897 6155 133,974 Deletion: 4.59%
Substitution: 3.67%

This Article

  1. RNA 32: 115-130