MUTACLASH: identifying functional small RNA target sites using crosslinking-induced mutations

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FIGURE 6.
FIGURE 6.

CIMs containing miRNA targeting sites identified from human AGO-1 CLASH data sets overall display better miRNA targeting scores than those sites without CIMs. (A) Comparison of miRNA targeting scores between those without mutation and those with deletion from the hybrids of human AGO-1 miRNA CLASH data. The statistical significance (P-value) of the difference in fold change was calculated by the Mann–Whitney U test and the permutation test. (B) Comparison of miRNA targeting scores with low abundant reads between those without mutation and those with deletion from the hybrids of human AGO-1 miRNA CLASH data. The statistical significance (P-value) of the difference in fold change was calculated by the Mann–Whitney U test and the permutation test.

This Article

  1. RNA 32: 115-130