Seb1 correlates with pausing in vivo. (A) Seb1 might act as a positive or negative regulator of the Pol II pausing. Two example genes showing the opposite effect on pausing in seb1-1 cells. (B) Metaprofile for the subset of genes exhibiting increased or decreased pausing index in the promoter region (NET-seq) for reference and the seb1-1 strain. (C) Association between Pol II pausing (PRO-seq) and genes with Seb1 cross-linking in the promoter region. The left panel depicts PRO-seq signal of all genes, and the middle panel presents genes stratified according to the pausing index (quantiles). The right panel shows genes grouped based on the presence or absence of Seb1 cross-linking in the promoter region. Total number of genes in each panel n = 3015.
