RNA G-quadruplex structure targeting and imaging: recent advances and future directions

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FIGURE 1.
FIGURE 1.

Structural diversities and biological functions of RNA G-quadruplexes. (A) The chemical structure of a G-quartet and the representative topologies of intermolecular and intramolecular G-quadruplex structures. (B) Representative three-dimensional structure of RNA G-quadruplexes. Protein Data Bank (PDB ID): 2KBP, 8X0S, and 6K84. (C) Representative biological roles of RNA G-quadruplexes in both coding mRNAs and noncoding RNAs (Dumas et al. 2021; Caterino and Paeschke 2022; Kharel et al. 2023; Sahayasheela and Sugiyama 2024; Shukla and Datta 2024).

This Article

  1. Published in Advance June 5, 2025, doi: 10.1261/rna.080587.125 RNA 31: 1053-1080

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