Dynamic RNA binding and unfolding by nonsense-mediated mRNA decay factor UPF2

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FIGURE 6.
FIGURE 6.

Model of UPF2–RNA interactions. Our data suggest a highly dynamic UPF2 structure and different RNA complex formation in the presence and the absence of UPF1 and/or UPF3B. UPF1 is activated by UPF2 and then weakly tethered to RNA. UPF3B can stabilize UPF1–UPF2's association with RNA, and UPF2 can support UPF1's RNA unfolding activity, corroborating mRNA degradation.

This Article

  1. Published in Advance April 17, 2025, doi: 10.1261/rna.080300.124 RNA 31: 933-948

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