DIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability in mice

Development of chimeric embryos. (A) Schematic representation of chimeric embryo construction. Diploid 4-cell embryos from Dis3l^+/− × Dis3l^+/− mating (white) were covered with two previously prepared tetraploid 2-cell WT embryos (magenta). (B) Chimeric embryos implantation rate after transfer to recipient females and percentage of those implanted embryos that fully developed to term. (C) Genotype distribution of chimeric pups developed to term. No Dis3l^−/− embryos developed fully.