Circuit logic: interdependent RNA modifications shape mRNA and noncoding RNA structure and function

7SK snRNP complexes and conformations are associated with distinct RBPs and posttranscriptional modifications. Schematic of P-TEFb-sequestering and alternative 7SK snRNP complexes. The P-TEFb-sequestering 7SK snRNP is characterized by low levels of m⁶A, while hnRNP- and BAF-bound 7SK is methylated by METTL3 and adopts a different conformation. 7SK secondary structure adapted from Olson et al. (2022).