Natalia Bartyś; Jolanta Lisowiec-Wąchnicka; Anna Pasternak

Thermodynamic control of mismatch discrimination for extensive splicing regulation of PKM pre-mRNA

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIGURE 5.

The influence of modified nucleotides on mismatch discrimination. (A) Difference in thermodynamic stability between complementary and mismatched duplex, $\text{[math]}$ (kcal/mol) (B) mismatch discrimination change, $\text{[math]}$ (kcal/mol) in reference to unmodified duplex.