Cytoplasmic regulation of the poly(A) tail length as a potential therapeutic target

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FIGURE 6.
FIGURE 6.

Model of the adaptive response to chronic stress. Sustained UPR occurs in two sequential phases. Acute phase: transient activation via eIF2α phosphorylation, allowing the permissive translation of uORF-containing mRNAs, including CPEB4 mRNA. Chronic phase: mediated by translational activation and increased stability of CPE-containing transcripts, including CPEB4.

This Article

  1. Published in Advance January 13, 2025, doi: 10.1261/rna.080333.124 RNA 31: 402-415

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