Cytoplasmic regulation of the poly(A) tail length as a potential therapeutic target

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FIGURE 5.
FIGURE 5.

Cytoplasmic regulation of poly(A) tail length is controlled by a double equilibrium of cis-acting elements (AREs vs. CPEs) and trans-acting factors (TTP vs. HuR and CPEB1 vs. CPEB4). The activity of the trans-acting factors is, in turn, regulated by kinases acting in a coordinated manner on AREBP and CPEBs.

This Article

  1. Published in Advance January 13, 2025, doi: 10.1261/rna.080333.124 RNA 31: 402-415

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