FIGURE 4.
The activity of CPEBs 2–4 as translation regulators depends on phase separation. Unphosphorylated CPEBs undergo liquid–liquid phase separation, repressing the translation of target mRNAs. Hyperphosphorylation by ERK2 and Cdk1 induces changes in the charge pattern, leading to condensate disassembly and promoting translational activation of CPEB4 targets. Phase separation properties rely on the intrinsically disordered NTD. Image adapted with permission from Guillen-Boixet et al. (2016).
