FIGURE 3.
The yin and yang of editing and inflammation. ADAR1 (Adar) expression is controlled by type I IFNs. Consequently, inflammatory processes that lead to type I IFN expression will increase the editing signature in cells. Conversely, lack of ADAR1 editing leads to MDA5 activation, which also leads to type I IFN production, which will then turn on Adar expression. Therefore, in inflammatory processes, it is difficult to distinguish cause or effect of an inosine signature without understanding the primary causal connections underlying altered inosine signatures in inflamed tissues.
