RNA editing in disease: mechanisms and therapeutic potential

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FIGURE 2.
FIGURE 2.

Inosine prevents MDA5 polymerization and activation of IFN production. MDA5 polymerizes along extended, dsRNA structures, which leads to the activation of type I IFNs. This happens mainly along viral dsRNAs to initiate an antiviral defense program. Endogenous RNAs are normally edited by inosines, which prevents MDA5 polymerization.

This Article

  1. Published in Advance January 2, 2025, doi: 10.1261/rna.080331.124 RNA 31: 359-368

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