FIGURE 3.
AlphaFold-Multimer predicted structures of the SF3B1–SUGP1–DHX15 heterotrimer and SF3B1–SUGP1 interface. (Left) Schematic drawing of the AF-M predicted structure of the SF3B1–SUGP1–DHX15 heterotrimer. The SF3B1 HEAT domain (453–1304) is shown in blue, with SF3B1 H4–H7 (606–756) shown in cyan. SUGP1 (441–645) is indicated in red, with the G-patch (560–606) shown in purple. DHX15 (121–795) is yellow. (Right) AlphaFold-Multimer–predicted interactions between the C-terminal residues of SUGP1 and SF3B1 hotspot residues mutated in cancer. (Figure adapted with modifications from Zhang et al. 2023.)
