The unfolding landscape of RNA and disease
- Maria Carmo-Fonseca1,2 and
- Juan Valcárcel3,4,5
- 1Gulbenkian Institute for Molecular Medicine, 1649-028 Lisbon, Portugal
- 2Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal
- 3Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain
- 4Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain
- 5Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain
- Corresponding author: carmo.fonseca{at}medicina.ulisboa.pt
This extract was created in the absence of an abstract.
The diversity of fundamental functions that RNA molecules carry out in living cells is truly overwhelming. Their molecular roles span from being universal conveyors of genetic information, to catalyzing key processes such as protein synthesis or RNA splicing, to serving as molecular scaffolds for macromolecular assemblies and condensates that help to organize and regulate cellular functions. Not surprisingly, alterations in RNA metabolism are at the root of a wide (and expanding) variety of pathologies. Given the intense research efforts and volume of literature on the topic of RNA and disease, our aim for this Special Issue has been to recruit inspiring leaders in this area and ask them to provide their visions of the evolution of the field and forecast the future, encouraging them to provide their own opinions and personal perspectives.
It has long been assumed that a detailed understanding of mechanisms involved in RNA transactions will pave the …
