Rational design yields RNA-binding zinc finger domains with altered sequence specificity

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FIGURE 1.
FIGURE 1.

Design of ZRANB2 ZnF mutant and RBNS assay. (A) Domains of human ZRANB2 protein. (B) Structure of human ZRANB2 C′-ZnF in complex with GGU RNA (PDB: 3g9y) and the homology between N′-ZnF and C′-ZnF. (C) Schematics of the modified RBNS assay with the ZnF array.

This Article

  1. Published in Advance December 10, 2024, doi: 10.1261/rna.080329.124 RNA 31: 150-163

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