UPF1 shuttles between nucleus and cytoplasm independently of its RNA-binding and ATPase activities

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FIGURE 1.
FIGURE 1.

Design of the RNA-binding mutant UPF1-NKR. (A) Scheme of the human UPF1 short isoform, with the amino acid changes introduced in the RNA-binding mutant (NKR) depicted in red or the ATPase mutant (DE), shown in blue. (B) The localization of the NKR and DE residues is depicted within the crystal structure of human Upf1ΔCH in complex with six ribonucleotides of a U15 RNA and ADP:AlF4−.

This Article

  1. Published in Advance October 7, 2025, doi: 10.1261/rna.080476.125 RNA 31: 1872-1885

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