Integrated NMR and MD structure and dynamics of the stem–loop-II motif (s2m) from the Omicron variant of SARS-CoV-2

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FIGURE 3.
FIGURE 3.

NMR-derived dynamics of s2m_omicron. (A) 1H, 13C heteronuclear NOE of the C1′ ribose (upper panel) and the C8/C6 aromatic resonances (lower panel). The loop of s2m_omicron is highlighted in magenta. Nucleotide C8 overlapped with other resonances and is therefore highlighted in red. (B) 1H, 13C HSQCs of the aromatic H6–C6/H8–C8 resonances from 287 K (blue) to 298 K (red). The resonance assignment is annotated.

This Article

  1. Published in Advance September 19, 2025, doi: 10.1261/rna.080576.125 RNA 31: 1766-1787

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