Understanding off-target growth defects introduced to influenza A virus by synonymous recoding

TABLE 1.

Properties of CpG modified PR8 IAVs recoded in segment 5

Mutation Recoded region No. CpGs ΔCpG No. UpAs Δ UpA
Wild-type segment 5 43 52
CDLR 159–1404 43 52
CpGH 162–1413 129 +86 54 +2
CpGH/A.PR8 628–1413 100 +57 53 +1
CpGH/B.PR8 151–624; 986–1413 110 +67 48 −4
CpGH/C.PR8 151–986 91 +48 58 +6
CpGH/D.PR8 151–297; 783–1413 98 +55 49 −3
CpGH/E.PR8 151–780; 1283–1413 94 +51 53 +1

This Article

  1. RNA 31: 1557-1574