Discrete measurements of RNA polymerase and reverse transcriptase fidelity reveal evolutionary tuning

TABLE 1.

Error rates (×10−6) for polymerases

Enzyme Substitution Deletion Insertion Total
T7 38 ± 5 2 ± 0 13 ± 1 53 ± 6
Induro 57 ± 3 6 ± 1 49 ± 4 113 ± 2
L1-RT 220 ± 4 9 ± 0 49 ± 2 278 ± 6
FBu 117 ± 67 7 ± 1 52 ± 12 175 ± 62

This Article

  1. Published in Advance June 28, 2024, doi: 10.1261/rna.080002.124 RNA 30: 1246-1258

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