TABLE 1.

IC50 values (nM) of TMPyP4 or PDS inhibition of CST–PP synthesis or binding to the DNA template indicated

IC50_synthesis and IC50_binding are defined as the concentration of small molecules required to inhibit synthesis or binding by half.
^aIC50 and SEM calculated from n = 5 independent replicates.
^bIC50 and SEM calculated from n = 4 independent replicates.
^cIC50 and SEM calculated from n = 6 independent replicates.
^dIC50 and SEM calculated from n = 3 independent replicates.

Small molecule telomerase inhibitors are also potent inhibitors of telomeric C-strand synthesis