Small molecule telomerase inhibitors are also potent inhibitors of telomeric C-strand synthesis

PDS stabilizes template DNA secondary structure. (A) CD spectra of 9xTEL in NaCl with and without 10-fold molar excess PDS. (B) CD spectra of 9xTEL in LiCl with and without 10-fold molar excess PDS. (C) Thermal melting of 9xTEL in NaCl with and without 10-fold molar excess PDS. The CD was monitored at 290 and 260 nm and normalized between 1 and 0 or between −1 and 0, respectively. (D) CD spectra of 9xnoGG in NaCl with and without 10-fold molar excess PDS. (E) CD spectra of 9xnoGG in LiCl with and without 10-fold molar excess PDS. (F) Thermal melting of 9xnoGG in NaCl with and without 10-fold molar excess PDS. The CD was monitored at 260 nm and normalized between 1 and 0.