Small molecule telomerase inhibitors are also potent inhibitors of telomeric C-strand synthesis

TMPyP4 stabilizes the template DNA secondary structure. (A) CD spectra of 9xTEL in NaCl with and without 10-fold molar excess TMPyP4. (B) Thermal melting of 9xTEL in NaCl with and without 10-fold molar excess TMPyP4. The CD was monitored at 290 and 260 nm and normalized between 1 and 0 or between −1 and 0, respectively. (C) CD spectra of 9xTEL in LiCl with and without 10-fold molar excess TMPyP4. (D) CD spectra of 9xnoGG in NaCl with and without 10-fold molar excess TMPyP4. (E) Thermal melting of 9xnoGG in NaCl with and without 10-fold molar excess TMPyP4. CD was monitored at 260 and 240 nm and normalized between 1 and 0 or between −1 and 0, respectively. (F) CD spectra of 9xnoGG in LiCl with and without 10-fold molar excess TMPyP4.