Small molecule telomerase inhibitors are also potent inhibitors of telomeric C-strand synthesis

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FIGURE 2.
FIGURE 2.

TMPyP4 inhibits CST–PP binding to template DNA. (A) Representative gels of CST–PP binding to radiolabeled template DNA in NaCl/KCl (left) or LiCl (right) following incubation of DNA with increasing concentrations of TMPyP4 (twofold dilutions from 3200 nM). (T) Template, (T–P) template–protein complex, (W) well. (B) Plot of fraction DNA bound at each concentration of TMPyP4 normalized to fraction bound with no inhibitor in NaCl/KCl or LiCl. Points represent mean values and error bars represent SD for n = 6 independent experiments, except 9xnoGG in Li+ (n = 4).

This Article

  1. Published in Advance June 25, 2024, doi: 10.1261/rna.080043.124 RNA 30: 1213-1226

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