Regulation of hexA/pecT by ArcZ in Dickeya and Photorhabdus. Direct and indirect targets of ArcZ are shown in Dickeya (green panel) and Photorhabdus (brown panel). Green arrows indicate activation, red arrows indicate repression, and black arrows indicate either translation or activity. In Dickeya, ArcZ inhibits the translation of pecT, which prevents the inhibition of rsmB transcription by PecT. RsmB is a small Hfq-independent regulatory RNA that binds to RsmA and prevents it from repressing the expression of T3SS and pectinases. In Photorhabdus, ArcZ inhibits the translation of hexA and thus enhances the production of secondary metabolites, which are essential for nematode symbiosis. Figure was created with BioRender.com.
