ArcZ targets in Salmonella typhimurium. Green arrows indicate activation, red arrows indicate repression, and black arrows indicate either translation or activity. ArcZ represses the expression of STM3216, a potential chemoreceptor acquired through horizontal gene transfer. As previously described, ArcZ modulates the response to oxidative stress by repressing tpx mRNA. Additionally, ArcZ represses the translation of sdaC mRNA, which is involved in serine catabolism. ArcZ and FnrS inhibit the translation of hilD, which is responsible for activating the T3SS synthesis. However, fnrS is transcribed under anoxic conditions due to Fnr, whereas arcZ is transcribed under strong aerobic conditions. Therefore, the activation of T3SS is limited by the presence of oxygen. Figure was created with BioRender.com.
