Regulation of the Drosophila transcriptome by Pumilio and the CCR4–NOT deadenylase complex

Computational modeling of Pum-mediated regulation of mRNAs identifies informative features. Leave-one-out analysis of a linear regression model applied to six influential features of Pum repression, labeled on the x-axis. The information contributed to the model by each feature was quantified with the change in the Bayesian Information Criterion (ΔBIC), where the difference was calculated as BIC_{1 left out} − BIC_{full model}, resulting in a positive ΔBIC value for informative features in the model.