Molecular basis of human poly(A) polymerase recruitment by mPSF

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FIGURE 4.
FIGURE 4.

Model of PAPOA regulation. Structural and biochemical data suggest different PAPOA conformations. The PAPOAC can fold back onto the PAPOA structured core in a potential autoregulatory conformation. This conformation is released in the presence of mPSF, with FIP1 docking onto the structured core and PAPOAC interacting with CPSF160. The PAPOAC–CPSF160 interaction appears to provide a second anchoring point for tethering the poly(A) polymerase more stably to mPSF.

This Article

  1. Published in Advance March 27, 2024, doi: 10.1261/rna.079915.123 RNA 30: 795-806

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