A comparative analysis of peptide-delivered antisense antibiotics using diverse nucleotide mimics

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIGURE 4.
FIGURE 4.

Antibacterial activity of KFF-ASO conjugates. Growth of Salmonella was monitored in the absence or presence of varying concentrations of seven different KFF-ASO conjugates or the (KFF)3KK(N3) peptide control. PNA, PMO, and the cationic carrier peptide control are depicted in shades of yellow, whereas negASOs are in shades of blue. Water control is shown in red. Graphs are representative examples of two independent experiments.

This Article

  1. Published in Advance February 27, 2024, doi: 10.1261/rna.079969.124 RNA 30: 624-643

Current Issue

  1. July 2026, 32 (7)
  1. Current Issue
  1. Alert me to new issues of RNA