High-resolution RNA tertiary structures in Zika virus stem–loop A for the development of inhibitory small molecules

Selection of molecules for RNA-binding assay. (A) Workflow of generating the list of 12 molecules for RNA-binding assay. The number of chemicals selected after each step is listed on the arrows. Manually selected compounds are shown in black boxes. (B) Compounds identified by Inforna. Five compounds identified by Inforna matched the exact sequence motifs of the bottom stem U-bulge (Inforna ID: 112, 295, 784, 924) or top stem G-bulge motifs (Inforna ID: 1144).