2′-O-methylation (Nm) in RNA: progress, challenges, and future directions

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FIGURE 3.
FIGURE 3.

Effects of Nm on RNA structure and protein binding. Nm stabilizes the C3′-endo conformation of the ribose moiety of nucleotides (A) and stabilizes RNA conformations in which Nm is in an RNA duplex (B). Proteins may selectively bind RNA with Nm (C) or may have decreased affinity for RNA with Nm (D). Created with BioRender.com.

This Article

  1. Published in Advance March 26, 2024, doi: 10.1261/rna.079970.124 RNA 30: 570-582

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