Structural and functional effects of inosine modification in mRNA

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FIGURE 2.
FIGURE 2.

(A) Biological consequences of inosine modification at specific locations in the mRNA. (B) Proposed editing of an ADAR dimer at tandem A–U sites. Editing leads to the formation of a highly destabilized duplex which can no longer bind and activate the dsRNA sensor, MDA5. (dsRBD) dsRNA binding domain.

This Article

  1. Published in Advance March 26, 2024, doi: 10.1261/rna.079977.124 RNA 30: 512-520

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