KDM5B negatively correlates with the expression of miR-140-3p in primary human AML. (A) Divergent alterations of the miR-140-3p in human cancers. Data were generated from cBioPortal (http://www.cbioportal.org/). (B) Expression levels of miR-140-3p in normal granulocytes (n = 13), monocytes (n = 6), and AML patients (n = 18). Data were analyzed from the published GSE51908 data set. (C) Expression levels of miR-140-3p in HDs (n = 8) and AML patients with (n = 26) or no (n = 10) relapse. Data were analyzed from the published GSE209871 data set. (D) Expression levels of miR-140-3p were measured in peripheral monocytes from HDs (n = 6) and AML patients (n = 5). (E) The expression levels of KDM5B and miR-140-3p were measured in AML patients (n = 16). Data represent the mean + SD (D). (*) P < 0.05, (**) P < 0.01, and (***) P < 0.001, by Student's t-test (B–D).
