Differential miRNA expression in RTT autopsy samples. Nanostring data on total miRNA levels in temporal cortical tissue from T158M (n = 3) and R255X (n = 5) RTT patients. (A) Overview of differentially expressed microRNAs (DEMs) in the temporal cortex of RTT patients, comparing the combined “all RTT” group with neurotypical controls. The analysis identified 78 DEMs with ∼16-fold higher expression and 67 DEMs with around threefold lower expression in RTT individuals compared to controls. (B) Comparison of the average fold change of upregulated DEMs common to both T158M and R255X mutations. The data revealed a significantly greater average fold change in the T158M group compared to the R255X group ([*] P = 0.02352, Student's t-test). Data are presented as mean ± SEM. Refer to Supplemental Figure S1 and Table S2 for additional information.
