Abolished frameshifting for predicted structure-stabilizing SARS-CoV-2 mutants: implications to alternative conformations and their statistical structural analyses

TABLE 2.

Minimum free energies computed for longer SARS-CoV-2 FSE constructs after DMS-MaP and ShapeKnots

SHAPEKnots 3_6 3_5 3_3 3_1 2_1 3_5*
87 (In 156 nt) – −36.1 kcal/mol – – −33.7 kcal/mol −33.6 kcal/mol
87 (In 222 nt) – – – – −55.7 kcal/mol −53.1 kcal/mol

This Article

  1. Published in Advance July 31, 2024, doi: 10.1261/rna.080035.124 RNA 30: 1437-1450

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