TABLE 1.
Minimum free energies computed for shorter SARS-CoV-2 FSE constructs after DMS-MaP and ShapeKnots
| SHAPEKnots | 3_6 | 3_5 | 3_3 | 3_1 | 2_1 | 3_5* |
|---|---|---|---|---|---|---|
| 87 nt (6XRZ) | −42.4 kcal/mol | −40.4 kcal/mol | −39.4 kcal/mol | – | – | – |
| 66 nt (7LYJ) | −45.0 kcal/mol | – | – | – | – | – |
| 65 nt (7MLX) | −32.9 kcal/mol | – | – | −30.3 kcal/mol | – | – |
| 77 nt | −42.5 kcal/mol | −40.8 kcal/mol | −40.2 kcal/mol | – | – | – |
| 3_6 Stabilizing | −32.8 kcal/mol | – | – | – | – | – |
| 3_5 Stabilizing | – | −39.9 kcal/mol | – | – | – | – |
| 3_3 Stabilizing | – | – | −24.3 kcal/mol | – | – | – |
