Cover image

Neuroblastoma oncogene mRNA G-quadruplex (PDB id: 7SXP; Balaratnam S, Torrey ZR, Calabrese DR, Banco MT, Yazdani K, Liang X, Fullenkamp CR, Seshadri S, Holewinski RJ, Andresson T, et al. 2023. Investigating the NRAS 5' UTR as a target for small molecules. Cell Chem Biol 30: 643–657.e8). The neuroblastoma RAS oncogene is deregulated and highly mutated in cancers including melanomas and acute myeloid leukemias. The 5' untranslated region of the RAS messenger RNA contains a G-quadruplex (G4) that regulates translation. The RNA G-quadruplex is displayed in NDB colors: A—red, C—yellow, G—green, U—cyan. Potassium ions (orange spheres) are bound within the central pore. Cacodylate anions are shown in purple. Cover image provided by the Nucleic Acid Knowledgebase (nakb.org). Image created using Mol* (Sehnal D, Bittrich S, Deshpande M, Svobodová R, Berka K, Bazgier V, Velankar S, Burley SK, Koča J, Rose AS. 2021. Nucleic Acids Res 49: W431–W437).