Ancestry of RNA/RNA interaction regions within segmented ribosomes

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FIGURE 1.
FIGURE 1.

Secondary structure representation of the ribosomal segments from T. brucei and E. gracilis. Segments are drawn over the 28S rRNA secondary structure from S. cerevisiae, derived from crystallographic structure data (Petrov et al. 2014). Equivalences were defined using structural alignments as described in the Materials and Methods section. (A) Secondary structure shows the 5S (brown), the two large and four small segments that comprise the T. brucei LSU rRNA. 5.8S (blue) and rRNA-α (red) largely correspond to domains I and II. srRNA-I (orange) grossly corresponds to domain III. rRNA-β largely corresponds to domains IV and V. srRNA-II (cyan), srRNA-III (magenta), and srRNA-IV (purple) correspond to domain VI. (B) Secondary structure shows the 5S (brown) and the 14 segments that comprise the E. gracilis LSU rRNA. 5.8S/LSU-1 (red), LSU-2 (light blue), LSU-3 (yellow), and LSU-4 (rose) largely correspond to domain I. LSU-5 (light green) and LSU-6 (purple) grossly correspond to domain II. The last part of LSU-6 (purple), LSU-7 (orange), and the beginning of LSU-8 (magenta) largely correspond to domain III. Most of LSU-8 (magenta) corresponds to domain IV. The last part of LSU-8 (magenta) and LSU-9 (cyan) correspond to domain V. LSU-10 (green), LSU-11 (dark teal), LSU-12 (lavender), LSU-13 (dark blue), and LSU-14 (light brown) correspond to domain VI.

This Article

  1. RNA 29: 1388-1399