Which came first: the chicken, the egg, or guanine?

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FIGURE 3.
FIGURE 3.

The programmability of polyG using G-tetrads as the recognition (A) and the structural (B) elements. According to the quadruplex domain (QD) folding pattern, a homopolymer (in this case G30) represents specifically arranged G3 and G6 segments (blue) linked by single Gs (black) and it is preprogrammed to fold into two QD domains stacked to each other. The gray discs represent the G-tetrads, and the curved black lines correspond to the Z-shaped (or propeller) loops formed by single Gs.

This Article

  1. Published in Advance June 7, 2023, doi: 10.1261/rna.079613.123 RNA 29: 1317-1324

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