Dynamically regulated transcription factors are encoded by highly unstable mRNAs in the Drosophila larval brain

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FIGURE 6.
FIGURE 6.

RNAs that are highly regulated during development are rapidly degraded. The stability percentile of RNAs (both mRNAs and ncRNAs) that are annotated as being involved in neural fate determination or early patterning of the Drosophila embryo are shown. For neural fate determination, the RNAs are a combination of temporal transcription factor genes and other genes that undergo temporal regulation in neural precursor cells (Doe 2017). For pattern formation, the genes were taken from a curated list hosted on the Interactive Fly website and encompassing gene sets known as the gap genes and the pair-rule genes (Brody 1999). Most of these genes are transcription factors (TFs); the non-TFs are indicated. Genes that are in our group of extended H3K27me3 genes (me3) are also indicated.

This Article

  1. RNA 29: 1020-1032