Exploring the targeting spectrum of rocaglates among eIF4A homologs

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIGURE 2.
FIGURE 2.

Scatter plot showing correlation between rocaglate-induced clamping to eIF4A1 and eIF4A3. The ΔmP obtained with eIF4A1•AMPPNP•poly r(AG)8 and eIF4A3•AMPPNP•poly r(AG)8 was measured for each compound (10 µM) in duplicate and is plotted. Pearson R2 = 0.89.

This Article

  1. Published in Advance March 7, 2023, doi: 10.1261/rna.079318.122 RNA 29: 826-835

Current Issue

  1. July 2026, 32 (7)
  1. Current Issue
  1. Alert me to new issues of RNA