Duf89 abets lncRNA control of fission yeast phosphate homeostasis via its antagonism of precocious lncRNA transcription termination

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FIGURE 14.
FIGURE 14.

lncRNA control of Pho1 expression is tunable by genetic maneuvers affecting 3′-processing/termination. prt lncRNA synthesis represses pho1 mRNA transcription in phosphate-replete conditions. States of pho1 derepression (A) and hyperrepression (B) at the prt-pho1 locus are achieved by changes in prt lncRNA 3′-processing/termination efficiency. The genetic perturbations that elicit these effects are indicated on the right.

This Article

  1. Published in Advance March 7, 2023, doi: 10.1261/rna.079595.123 RNA 29: 808-825

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