RNAi in cell nuclei: potential for a new layer of biological regulation and a new strategy for therapeutic discovery

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FIGURE 6.
FIGURE 6.

Model showing assembly of different protein complexes in the nucleus based on recruitment of cofactors by RNAi scaffolding protein, TNRC6. AGO loaded with small RNA guide facilitates recognition of RNA targets, and TNRC6 bridges diverse protein interactions (Hicks et al. 2017).

This Article

  1. Published in Advance January 19, 2023, doi: 10.1261/rna.079500.122 RNA 29: 415-422

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